From retina to cortex: An unexpected division of labor

Neurons in our brain do a remarkable job of translating sensory information into reliable representations of our world that are critical to effectively guide our behavior. The parts of the brain that are responsible for vision have long been center stage for scientists’ efforts to understand the rules that neural circuits use to encode sensory information. Years of research have led to a fairly detailed picture of the initial steps of this visual process, carried out in the retina, and how information from this stage is transmitted to the visual part of the cerebral cortex, a thin sheet of neurons that forms the outer surface of the brain. We have also learned much about the way that neurons represent visual information in visual cortex, as well as how different this representation is from the information initially supplied by the retina. Scientists are now working to understand the set of rules—the neural blueprint— that explains how these representations of visual information in the visual cortex are constructed from the information provided by the retina. Using the latest functional imaging techniques, scientists at MPFI have recently discovered a surprisingly simple rule that explains how neural circuits combine information supplied by different types of cells in the retina to build a coherent, information-rich representation of our visual world.

Vision begins with the spatial pattern of light and dark that falls on the retinal surface. One important function performed by the neural circuits in the visual cortex is the preservation of the orderly spatial relationships of light versus dark that exist on the retinal surface. These neural circuits form an orderly map of visual space where each point on the surface of the cortex contains a column of neurons that each respond to a small region of visual space— and adjacent columns respond to adjacent regions of visual space. But these cortical circuits do more than build a map of visual space: individual neurons within these columns each respond selectively to the specific orientation of edges in their region of visual space; some neurons respond preferentially to vertical edges, some to horizontal edges, and others to angles in between. This property is also mapped in a columnar fashion where all neurons in a radial column have the same orientation preference, and adjacent columns prefer slightly different orientations.

Things would be easy if all the cortex had to do was build a map of visual space: a simple one to one mapping of points on the retinal surface to columns in the cortex would be all that was necessary. But building a map of orientation that coexists with the map of visual space is a much greater challenge. This is because the neurons of the retina do not distinguish orientation in the first step of vision. Instead, information on the orientation of edges must be constructed by neural circuits in the visual cortex. This is done using information supplied from two distinct types of retinal cells: those that respond to increases in light (ON-cells) and those that respond to decreases in light (OFF-cells).  Adding to the complexity, orientation selectivity depends on having individual cortical neurons receive their ON and OFF signals from non-overlapping regions of visual space, and the spatial arrangement of these regions determines the orientation preference of the cell. Cortical neurons that prefer vertical edge orientations have ON and OFF responsive regions that are displaced horizontally in visual space, those that prefer horizontal edge orientations have their ON and OFF regions displaced vertically in visual space, and this systematic relationship holds for all other edge orientations.

So cortical circuits face a paradox: How do they take the spatial information from the retina and distort it to create an orderly map of orientation selectivity, while at the same time preserving fine retinal spatial information in order to generate an orderly map of visual space?  Nature’s solution might best be called ‘divide and conquer’.  By using imaging technologies that allow visualization of the ON and OFF response regions of hundreds of individual cortical neurons, Kuo-Sheng Lee and Sharon Huang in David Fitzpatrick’s lab at MPFI have discovered that fine scale retinal spatial information is preserved by the OFF response regions of cortical neurons, while the ON response regions exhibit systematic spatial displacements that are necessary to build an orderly map of edge orientation.  Preserving the detailed spatial information from the retina in the OFF response regions is consistent with evidence that dark elements of natural scenes convey more fine scale information than the light elements, and that OFF retinal neurons have properties that allow them to better extract this information. In addition, Lee et al. show that this OFF-anchored cortical architecture enables emergence of an additional orderly map of absolute spatial phase—a property that hasn’t received much attention from neuroscientists, but computer vision research has shown contains a wealth of information about the visual scene that can be used to efficiently encode spatial patterns, motion, and depth.

While these are important new insights into how visual information is transformed from retina to cortical representations, they pose a host of new questions about the network of synaptic connections that performs this transformation, and the developmental mechanisms that construct it, questions that the Fitzpatrick Lab continues to explore.

 


Topology of ON and OFF inputs in visual cortex enables an invariant columnar architecture

Kuo-Sheng Lee, Xiaoying Huang, and David Fitzpatrick.

Nature, Published online, April 27, 2016.
DOI: 10.1038/nature17941

 

MPFI Honored with Lifees Award at eMerge Americas in Miami

Award Recognizes MPFI’s Commitment to Helping Students Succeed, Industry Grow

Miami, FL – The Max Planck Florida Institute for Neuroscience (MPFI) recently received the Life Sciences South Florida (LSSF) Lifees Award at eMerge Americas in Miami, which brings together the top government officials and business leaders from around the world to explore how public-private partnerships can leverage technologies to transform our communities. The Lifees Award honors organizations, like MPFI, that are leaders in the life sciences and have demonstrated a commitment to furthering the industry through education and collaboration.

“Enriching science education is an important component of the Max Planck Society philosophy around the world,” said Dr. David Fitzpatrick, MPFI CEO and Scientific Director. “The Max Planck Florida Institute for Neuroscience is committed to offering programs and activities to enhance interest in and foster understanding of bioscience research at all levels of education. We also seek opportunities, like taking part in Florida Atlantic University’s Jupiter Life Science Initiative, where we can collaborate with higher education and other life science institutions to further the industry’s efforts both locally and worldwide. The pioneering basic research performed at MPFI is laying the framework for tomorrow’s great discoveries, and we are proud to have been recognized as a leader among our peers. We look forward to continuing to cultivate this culture of education and collaboration within the life sciences in South Florida.”

MPFI was nominated for the Lifees Award by Raquel Rodriguez with McDonald Hopkins, LLC. Categories for the award include demonstration of student training and research activities, benefit to the scientific community and demonstration of community partnership.

“MPFI has demonstrated an immense commitment to the development of our South Florida life sciences industry,” said Saif Ishoof, Vice President for Engagement at Florida International University (FIU), who oversees the LSSF consortium on behalf of the Executive Committee of LSSF and Chair, President Mark B. Rosenberg of FIU. “The opportunities MPFI provides our local students and the research they conduct sets them apart, creating a large impact on our community.”

The institute is among only five recipients honored with the inaugural award, which was presented by LSSF, whose members include leaders of the top educational, economic development and research institutions in the region. LSSF seeks to establish an industry cluster in South Florida focused on life sciences, biotechnology, pharmaceuticals, diagnostics and information technology.

Among the programs listed during MPFI’s recognition is its partnership with Florida Atlantic University (FAU) in the creation of doctoral program in Integrative Biology with a concentration in Neuroscience. The program, known as IBAN (Integrative Biology and Neuroscience), provides students the opportunity to explore cutting-edge questions in neuroscience through the integration of multiple disciplines, different model systems and a broad spectrum of technologies. In addition, the award recognized MPFI and FAU’s collaboration with University of Bonn (Bonn, Germany), and the Center for Advanced European Studies and Research (Bonn, Germany), to globalize education in brain research with an all-new International Max Planck Research School (IMPRS) for Brain & Behavior.

Finally, MPFI’s community engagement through events, like the Brain Bee Challenge and public lectures at local high schools, were highlighted as examples of how the institute is sharing its wealth of knowledge and furthering scientific education among even the youngest aspiring scientists.


Pictured above: Dr. Matthias Haury, MPFI COO, and Mark Rosenberg, LSSF Chair and FIU President