Dagmar Wachten

Gaucher disease and the Sphinx

March 31, 2017 · by IMPRS-BB

Sphingosine inhibits the enzyme GBA2, thereby regulating the degradation of lipid-sugar compounds in cells. Sphingosine, a compound as enigmatic as the sphinx, plays a key role in the metabolic disorder Gaucher disease. Scientists from the Bonn research center caesar have… Read more »

How cortical circuits keep the balance in imbalance

December 15, 2016 · by IMPRS-BB

A recent study published in “Neuron” provides insights into the interplay between the cellular properties of single neurons, their connections and the network architecture. Cortical neurons receive thousands of excitatory and inhibitory signals, both from local and long-range circuits. To… Read more »

Biosensor measures signaling molecules within cilia

March 22, 2016 · by IMPRS-BB

Scientists can measure the dynamics of signaling molecules in subcellular compartments. Scientists of the Research Center caesar in Bonn, an Institute of the Max Planck Society, developed a new biosensor, which allows to measure nanomolar levels of the second messenger… Read more »

When the neuron’s doorman allows too much in

November 16, 2015 · by IMPRS-BB

(Above Image) This is what a neuron from the hippocampus of a rat looks like. The cell and it’s extensive processes are visualised using a fluorescent dye, filled via a glass pipette. The glass pipette, with dye, is shown on… Read more »